HomeScience & TechnologyNanocomputing shows that it can control a protein function

Nanocomputing shows that it can control a protein function

Scientists at Penn State say they have produced a nanocomputing agent that can control the function of a specific protein involved in cell movement and cancer metastasis. They say their research paves the way for the construction of complex nanoscale computers for the prevention and treatment of cancer and other diseases.

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Nanocomputing
Nanocomputing shows that it can control a protein function

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The team, which included Nikolay Dokholyan, G. Thomas, PhD, Passananti Professor, Penn State College of Medicine, and his colleagues, including Yashavantha Vishweshwaraiah, PhD, a postdoctoral fellow, created a "logical portal" that looks like a trans , which is a type of computer operation in which multiple inputs control one output. They published the study ("Two-input logic logic gateway for calculation in living cells") in Nature Communications.

The group's logical gateway included two areas of sensors designed to respond to two inputs - light and rapamycin. The team targeted focal adhesion protein kinase (FAK) because it is involved in cell adhesion and motility, which are early steps in the development of metastatic cancer.

The team introduced the modified gene into HeLa cancer cells and, using confocal microscopy, observed the cells in vitro. They studied the effects of each of the inputs separately, as well as the combined effects of the inputs, on the behavior of the cells.

They found that not only could they activate FAK quickly using light and rapamycin, but that this activation resulted in the cells suffering internal changes which enhanced adhesion capabilities, which reduced their mobility.

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Nanocomputing protein function
Nanocomputing shows that it can control a protein function

"We are showing for the first time that we can create a functional nanocomponent within living cells that can control cell behavior," Vishweshwaraiah continued. "We also discovered some interesting features of the FAK protein, such as the changes it causes in cells when activated."

Dokholyan noted that the team hopes to finally evaluate these nanocomputing factors in vivo within living organisms.

Source of information: genengnews.com

Teo Ehchttps://www.secnews.gr
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